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Wellness + Wisdom with Josh Trent

The Wellness + Wisdom Podcast is a global collective dedicated to mastering physical and emotional intelligence for humans to thrive in our modern world.

In this podcast together we gather, apply and embody the wisdom needed for authentic well-being in the 21st century.

Each episode is artfully crafted to go an inch wide and a mile deep into the Pentagon of Wellness: Physical, Emotional, Mental, Spiritual & Financial.

Your host Josh Trent asks the questions no one else will ask to garner the truth about how to live a life of confidence, freedom, and optimal wellness—this is where together we walk the path of courage to cross the gap between knowing and doing.

Learn from world class leaders in the fields of physical intelligence, breathwork, emotional intelligence, behavior change, wellness, nutrition, behavioral psychology, habits, mindset, fitness, health, strength training, organic supplementation, biohacking, body transformation, psychedelics, mindfulness, meditation, neuroscience, mental health, spirituality, consciousness, the (7) pillars of wellness to live life well and (EI²)™ Emotional Intelligence + Inventory.

Nov 28, 2023

Wellness + Wisdom | Episode 591

Do you know how to biohack your heart, body, and mind?

Dr. John Lieurance | Biohacking Big Souls: How UFC Fighters + Big Wave Surfers Holistically Heal Heart, Body + MindDr. John Lieurance, Naturopath and Chiropractic Neurologist, joins Josh Trent on the Wellness + Wisdom podcast, episode 591, to share how he treats celebrities to help them breathe well, which biohacking products you should be using every day, how endotoxins cause inflammation in the body, and why suppositories are more effective than IV.

"Everything stops working properly when you have too much inflammation in the body. You have areas that microbes can live and exist and secrete their excrement, right. Their toxic waste. This is called an endotoxin. And these endotoxins are literally at the root of all diseases. The 3 primary doorways are the nasal passage, the oral, the mouth, and the colon." - Dr. John Lieurance

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Dr. John Lieurance | Biohacking Big Souls: How UFC Fighters + Big Wave Surfers Holistically Heal Heart, Body + Mind

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In This Episode, Dr. John Lieurance Uncovers:

[01:30] How to Activate Your Pineal Gland

[07:00] MitoZen Blue Eyes + The Law of Attraction

[13:20] Pharmaceuticals VS Natural Supplements

[20:30] Methylene Blue Increases ATP Production

[26:40] The Negative Effects of Antibiotics

  • How methylene blue is produced.
  • Why physicians choose new solutions over the old ones, even though they are less efficient.
  • Unpacking how Josh found out about MARCoNS thanks to Dr. John.
  • How antibiotic resistance is created.
  • The benefits of butyrate.

[32:30] Endotoxins + Inflammation

  • Endotoxins are at the root of all diseases.
  • How toxins trigger inflammation in the body.
  • Ask your doctor to test your lipopolysaccharides (LPS), high-sensitivity C-reactive protein (HSCRP), MMP-9, and TGF-Beta-1.
  • Why chronic inflammatory response syndrome is common amongst people.
  • Dr. John's process of healing from Lyme disease.

[37:10] Best Tools for Biohacking + Healing Disease

[45:15] MitoZen Biohacking Products

[51:35] The Benefits of Melatonin

[57:15] What Is The Right Melatonin Dose?

  • Why you can take high melatonin doses regularly.
  • The melatonin study performed on Siberian hamsters cannot be compared to the human body.
  • How to dose melatonin according to your needs.
  • Why methylene blue is good for learning and storing short-term memory.

[01:06:40] Alter Your Stress Response

  • The role of norepinephrine during a stress response.
  • How traumatic experiences trigger stress hormones.
  • Why people with chronic infection feel a lot of anxiety.
  • One dose of methylene blue can improve memory consolidation which can treat phobias.
  • How methylene blue improves the mood.
  • Avoid serotonin syndrome reaction.
  • Francisco Gonzalez-Lima

[01:14:20] Functional Cranial Release

  • How Dr. John helped Dana White heal sleep apnea.
  • Why fighting is not only about violence but has a spiritual meaning.
  • How functional cranial release works.
  • Dura mater: the "tough mother" tissue in the brain.
  • Why Aboriginal peoples had less breathing and teeth problems.
  • Josh's experience getting his first function cranial release from Dr. John.

[01:23:40] Maintain Your Youth with NAD

  • The benefits of taking NAD and why our body needs it.
  • How our NAD gets depleted from our body.
  • Why we should fast regularly.
  • The reason why NAD+Max contains senolytics.
  • Why we want to activate or inhibit mTOR gene expression.

[01:30:05] Suppositories Are Better Than IV

  • Suppositories can have a greater absorption impact.
  • Why NAD suppository is better than NAD IV.
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  • Why Dr. John likes to use near infrared sauna.
  • Dr. John's perspective on what's going to happen in the future.
  • Why everything is better with friends and community.

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Power Quotes From The Show

Locus Coeruleus: The Blue Spot

"Locus coeruleus is the point of control master system to the entire system in the brain. We store the short-term memory. If we don't transfer the short-term memory to our upper cortex and integrate it, then we can't make sense of what's happening in the now as it relates to what's happened in the past to formulate in context our life, our mission, and our relationships." - Dr. John Lieurance

Melatonin: The Safest Molecule

"I would challenge anybody to bring me a molecule that has more testing showing safety than melatonin. There isn't. Every cell in your body makes it. We need melatonin to survive." - Dr. John Lieurance

Dura Mater

"The cranium is made up of separate bones which come together in unique ways to facilitate a motion called cranial rhythm. But there's a connective tissue layer just inside of the bones called the dura mater (tough mother). It's got 2000 pounds per square inch of tensile strength. It's very, very durable. And what happens when mothers are overly protective? The kid doesn't get to explore the environment and doesn't learn. The same thing happens with the neurological system when you have this bound connective tissue. It disrupts the flexibility, but it also causes the skull to be contracted and pulled into a collapsed position." - Dr. John Lieurance

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Links From Today's Show 

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About Dr. John Lieurance

Naturopath and Chiropractic Neurologist, Dr. John Lieurance, has been in private practice for over 27 Years.

Currently, with Advanced Rejuvenation, a Multi-Disciplinary Clinic, with a focus on Alternative and Regenerative Medicine, Naturopathic Medicine, Chiropractic Functional Neurology, Functional Cranial Release (FCR), Lumomed, Lyme Disease, Mold Illness, and many other Neurological Conditions.

His treatments have been proven very successful in treating many chronic neurological and chronic infection conditions.

He believes that toxins and infections are at the root of many conditions including Autoimmune, Parkinson’s, Alzheimer’s, Inner Ear Conditions, and most Degenerative Neurologic Conditions.


He is the Author of Melatonin: Miracle Molecule and he's working on his second book on Endonasal Cranial Therapy. As the developer of Functional Cranial Release, he teaches as well as certifies these methods to doctors around the world.


He is also the Chief Scientific Officer of MitoZen Scientific, a cutting-edge healthcare technology company that has a focus on powerful delivery systems such

Many of the products created are designed to be used for support for alternative practitioners to apply to chronic conditions such as mold toxicity (CIRS), heavy metal toxicity, autoimmune conditions, neurological diseases, and chronic inflammation.

Also, many “BioHackers” find them helpful to enhance cognition and physical performance!

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